Yes it is possible and for the most part when bowlers bowl a 300 hundred game, the next game that they bowl will not be so good or they lose carrier. The last game, they could end up bowling under 100 game but this is something that should not happen. I have seen a lot of things in bowling and I have seen bowlers miss a single pin spare to win the game. I seen bowlers throw a gutter ball when they only need 5 pins to win. Yes it possible in anything in bowling and every pin count in bowling.